The Spindle Assembly Checkpoint Current Biology Biology Diagrams Accurate chromosome segregation and spindle positioning during cell division are critical for genomic stability, with these processes regulated by the spindle assembly checkpoint (SAC) and spindle positioning checkpoint (SPOC) [1], [2].The SAC ensures that chromosomes are properly attached to the spindle before anaphase, preventing premature separation and aneuploidy [3], [4], while the SPOC Dynamics of spindle assembly and position checkpoints: Integrating molecular mechanisms with computational models Comput Struct Biotechnol J. 2025 Jan 10 including bistable switches driving spindle assembly checkpoint (SAC) activation, spatial organization principles underlying spindle position checkpoint (SPOC) signaling, and critical
Principles and dynamics of spindle assembly checkpoint signalling Spindle pole OFF ON MCC MCC APC/CCDC20 APC/CCDC20 Aurora B Anaphase onset Securin Cyclin B Separase CDK1 APC/CCDCc20 Principles and dynamics of spindle assembly checkpoint signalling Article 24 March 2023. Introduction. The spindle, first described in the 1880s 1 by
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics Biology Diagrams
The spindle assembly checkpoint (SAC, also known as mitotic or metaphase checkpoint) is a feedback-control system that operates during cell division in eukaryotic cells 1, 2, 3.The SAC monitors chromosome bi-orientation on the mitotic spindle, and as long as improperly attached chromosomes remain, it halts cells in mitosis and precludes passage into the final phases of cell division (Figure 1). Current Biology Review The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics Andrea Musacchio1,2 1Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany 2Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany Correspondence: andrea.musacchio@mpi-dortmund.mpg.de The transmission of a complete set of chromosomes to daughter cells during cell division is vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) ensures correct segregation by informing the cell cycle machinery of potential errors in the interactions of chromosomes with spindle microtubules prior to anaphase.
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint